Early Game Buy left to right. During laning phase, you want to use Splatter (1) whenever it's off-cooldown and constantly poke your enemies. If you're struggling, buy a healing item, then sell it later.
Lane Healing Buy one of those items to remain in lane and not miss out on souls! Sell the item you picked later.
Mid Game Buy left to right. Try to stay above 65% health to benefit from Enchanter's Emblem bonuses. Upon acquiring Echo Shard, your burst damage will be greatly increased as you'll be able to throw TWO Splatter (1) in a row and trigger Spirit Burn with ease.