If you realize at some point that the enemy is building Spirit Resistance against you during Late Game, consider those items
Spirit Rend requires you to shoot your enemy and land headshots
Crippling Headshot makes Headshots mandatory
Mystic Vulnerability and Escalating Exposure require you to land Splatter (1) or trigger Spirit Burn for them to work
Spirit Strike and Spirit Snatch will have you use Puddle Punch (3) to debuff your enemies! Finally, Silence Wave is a powerful debuff that will lower Spirit Resistance, Spirit Power while also Silencing your opponents.